CSIR-CCMB Researchers Identify Potential Tuberculosis Drug Targets
On November 10, 2026, scientists at the CSIR-Centre for Cellular and Molecular Biology (CCMB) in Hyderabad announced a significant advancement in the fight against tuberculosis (TB). The research team identified vulnerabilities within Mycobacterium tuberculosis, the bacterium responsible for TB, which could pave the way for the development of new medications.
Key Findings
The study, led by CCMB Director Vinay Kumar Nandicoori, focused on mapping the bacterium’s protein export machinery. Collaboration occurred with the Institute of Mathematical Sciences, Chennai, led by Areejit Samal, and the Translational Health Science and Technology Institute, Faridabad. Researchers analyzed the bacterium’s processes, identifying 92 key components and nearly 200 molecular reactions.
Targeted Pathways
Specifically, the team investigated the general Sec pathway, the Twin-Arginine Translocation (Tat) system, and specialized ESX secretion systems. Using CRISPR-based gene silencing, researchers reduced activity in the SecA1 and Tat pathways. Laboratory experiments demonstrated a sharp decline in bacterial growth both in cultures and within immune cells.
Impact on Bacterial Structure
Disruption of these pathways resulted in the export of over 100 proteins linked to SecA1 and approximately 140 linked to Tat. Furthermore, the research indicated damage to the bacterial cell membrane, rendering it unstable and more permeable.
Publication and Next Steps
The findings have been published in the peer-reviewed journal Molecular & Cellular Proteomics. According to the publication, developing new medicines will require several more years of research. India accounts for nearly a quarter of global TB cases and about a third of drug-resistant infections, highlighting the urgency of finding effective treatments.
Important Note
As of the current date, no further details regarding specific drug development plans or timelines have been announced by the researchers or any official organizations.
Source: GK Today.
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